Informatics Publishing Limited

V. Sai Kishore ¹, N. Balaji ¹, K. Srikanth ¹, J. Hemanth ¹

Affiliations
1 Bapatla College of Pharmacy, Bapatla-522101, IN

Abstract

Sun light causes damage to skin by inducing photoaging, photocarcinogenisis. Aloe vera is most popular in the treatment of dermatological disorders. In this study, in to the calamine lotion aloe gel (conventional lotion), a novel lotion containing freeze dried aloe powder beads and freeze dried aloe powder lotion were incorporated. The aim of this study is to compare the efficacy of novel lotion (freeze dried aloe powder beads and freeze dried aloe powder lotion) and conventional lotion (aloe gel). Aloe gel beads were prepared by using the ionic gelation technique. Beads were in spherical shape with a diameter of 0.510±0.143 mm. The novel, conventional lotion were evaluated for the colour, PH of preparation, sedimentation volume, redispersibility, spreadability, rheological, In vitro and In vivo sun protection factor(SPF). For conventional lotion SPF was found to be 6.39±0.1 where as for novel lotion containing freeze dried aloe powder beads SPF was found to be 13.52±0.21. It was found that novel lotion containing freeze dried aloe powder beads provides greater sunscreen protection than the conventional lotion. In vivo SPF values for novel lotion are higher than the conventional lotion.

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M. Sukanya ¹, V. Saikishore ², P. Y. Shanmukha ², K. Srikanth ²

Affiliations
1 Bapatla College of Pharmacy, Bapatla-522101, Andhra Pradesh, IN
2 Bapatla College of Pharmacy, Bapatla-522101, Andhra Pradesh, IN

Abstract

Pulsatile drug delivery systems (PDDS) are gaining importance in the field of pharmaceutical technology as these systems deliver the right dose at specific time at a specific site. These systems are designed according to the circadian rhythm of the body. The principle rationale for the use of pulsatile release is for the drugs where a constant drug release, i.e., a zero-order release is not desired. The release of the drug as a pulse after a lag time has to be designed in such a way that a complete and rapid drug release follows the lag time. Advantages of the pulsatile drug delivery system are reduced dose frequency; reduce side effects, drug targeting to specific site like colon and many more. Diseases wherein PDDS are promising include asthma, peptic ulcer, cardiovascular diseases, arthritis, attention deficit syndrome in children, and hypercholesterolemia. In pursuit of pulsatile release, various design strategies have been proposed, mainly including time controlling, stimuli induced, externally regulated and multiparticulate formulations. This review will cover methods with different polymeric systems like time controlling, internal stimuli induced (temperature induced and chemical stimuli-induced), and external induced (magnetic fields, ultrasound, electric fields and light stimulation) and multiparticulate system. The current article focuses on the diseases requiring PDDS, methodologies involved for the existing systems, recent update and PDDS product currently available in the market.

Keywords

Pulsatile Drug Release, Lag Time, Circadian Rhythm, Stimuli Induced, Multiparticulate.

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P. Srujana ¹, V. Sai Kishore ¹, K. Srikanth ¹, P. Y. Shanmukha ¹

Affiliations
1 Bapatla College of Pharmacy, Bapatla-522101, Andhra Pradesh, IN

Abstract

Aloe vera is a perennial, drought-resisting, succulent plant belonging to the Liliaceae family which, historically has been used for a variety of medicinal purposes. It has a vast traditional role in indigenous system of medicine like ayurveda, siddha, unani and homoeopathy. As a result of its use as folk medicine, it is claimed that aloe vera has wound and burn healing properties, antifungal activity, hypoglycemic or antidiabetic effects anti-inflammatory, anticancer, immunomodulatory and gastroprotective properties. Aloe vera is used in a variety of commercial products because of these therapeutic properties. The known biological activities of A. vera were briefly discussed and also further highlighted recently discovered effects and applications of the leaf gel. The present review is therefore, an effort to give a detailed survey of the literature on its traditional, phytochemical and pharmacological properties, Industrial processing technique and Industrial uses. With technological developments in the field of analytical chemistry it has become easier to isolate and characterise the chemical components of the leaf gel and it is expected that more information in this regard will become available in the future at a faster rate. More applications are discovered as research from different viewpoints is conducted on this versatile plant to provide a better understanding of its composition and effects. Further research needs to be done to unravel the myth surrounding the biological activity and the exploitation of aloe constituents.

Keywords

Aloe Vera, Phytochemical, Pharmacological, Cosmetic, Pharmaceutical, Food Industries.

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K. Rajani , V. Vijaya Bhaskara Reddy , K. Srikanth

Abstract

With the recent adoption and diffusion of the data sharing paradigm in distributed systems such as online social networks or cloud computing, there have been increasing demands and concerns for distributed data security. One of the most challenging issues in data sharing systems is the enforcement of access policies and the support of policies updates. Cipher text policy attribute-based encryption (CP-ABE) is becoming a promising cryptographic solution to this issue. It enables data owners to define their own access policies over user attributes and enforce the policies on the data to be distributed. However, the advantage comes with a major drawback which is known as a key escrow problem. The key generation center could decrypt any messages addressed to specific users by generating their private keys. This is not suitable for data sharing scenarios where the data owner would like to make their private data only accessible to designated users. In addition, applying CP-ABE in the data sharing system introduces another challenge with regard to the user revocation since the access policies are defined only over the attribute universe. Therefore, in this study, we propose a novel CP-ABE scheme for a data sharing system by exploiting the characteristic of the system architecture.

The proposed scheme features the following achievements: (1) the key escrow problem could be solved by escrow-free key issuing protocol, which is constructed using the secure two-party computation between the key generation center and the data storing center, (2)fine-grained user revocation per each attribute could be done by proxy encryption which takes advantage of the selective attribute group key distribution on top of the ABE. The performance and security analyses indicate that the proposed scheme is efficient to securely manage the data distributed in the data sharing system.

 

Keywords

Data sharing, attribute-based encryption, revocation, access control, removing escrow

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P. V. R. Ravindra Reddy ¹, P. Radhakrishna Prasad ¹, G. Chandra Mohan Reddy ¹, A. Sarotham Reddy ¹, K. Srikanth ¹

Affiliations
1 Dept. of Mechanical Engg., CBIT, Gandipet, Hyderabad, IN

Abstract

Friction Stir Welding (FSW) is a solid state welding process in which the heat for welding is produced by the relative motion between the tool and the two interfaces being joined. In this present study, AA-6082 alloy is friction stir welded for different combination of tool rotation speed and tool feed. Here a cylindrical tapered tool along with a profiled probe is rotated and fed at a constant traverse rate in to the joint. Taguchi technique is used to design the experiments. Total four experiments are conducted. The UTS and hardness for all four welded parts are measured by UTM and Vickers hardness tester respectively. Analysis is done and the optimum parameters are obtained and presented.

Keywords

Friction Stir Welding, Orthogonal Arrays, Taguchi, ANOVA, AA-6082.

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